Newcastle United’s reward for eliminating Carabao Cup holders Manchester United will be a trip to face Chelsea in the quarter-finals, while nine-time winners Liverpool host West Ham United.
In the other two games drawn on Wednesday, Everton will welcome Fulham and the two remaining non-Premier League sides will face off when Championship side Middlesbrough host Port Vale.
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Newcastle humiliated last year’s winners 3-0 at Old Trafford on Wednesday and will now face a struggling Chelsea side after securing a much-needed win over Blackburn Rovers.
West Ham should travel to Anfield with great confidence, having easily beaten Arsenal 3-1 at the London Stadium.
Only three of the remaining eight teams – Liverpool, five-time champions Chelsea and 2004 winners Middlesbrough – have lifted the League Cup before.
Port Vale reached the quarter-finals for the first time in their history after beating Mansfield Town in League Two 1-0 on Tuesday.
The quarter-final matches will be held in the week starting December 18.
Carabao Cup quarter-final draw:
Everton vs Fulham
Chelsea vs Newcastle
Port Vale vs Middlesbrough
Liverpool vs West Ham